Master of Science in Pharmaceuticals and Health Products. Active Principle" pathway. |  2023-2024

Activate all your mental resources to discover tomorrow's medicines :
creativity, team spirit, multidisciplinary knowledge, memory, enthusiasm, perseverance, optimism, realism.

General objective for M2 holders:

To be able to carry out an experimental mission as part of a multidisciplinary project involving the discovery, design, multiparametric optimization and selection of a new active ingredient. The multimodal teaching of this Master's degree, carried out in small classes 

Upon graduation, students will be able to :  

  • Join an interdisciplinary drug discovery team in the pharmaceutical or biotech industry, or in academia.
  • Join a technology transfer team or an investment company specializing in therapeutic innovation.
  • Preparing a thesis (PhD).

Skills based on basic factual knowledge :

The different types of therapeutic target. Understand the molecular structure and function of current and potential targets of active ingredients.

Molecular basis of the pharmacological action of the active ingredient. Knowledge of the thermodynamic, kinetic and structural bases of the interaction of the active ingredient with living components. Structure-property relationships.

Identification and qualification of a therapeutic target: understand the reasoning and produce or assemble the scientific data needed to assess a new gene or protein as a therapeutic target.

Basic procedural skills :

Modeling and measuring molecular interactions in drug discovery. Use computer tools and public or private databases to help design an active ingredient. Define and implement appropriate experimental techniques to measure the potency, affinity, kinetics and functionality of a ligand-receptor interaction.

Chemical aspects of drug development. Design a synthesis route for a low-molecular-weight organic active ingredient.

Analytical tools : Choisir et mettre en œuvre une méthode analytique adaptée à l’identification, la purification, et la mesure de la pureté (y compris stéréochimique) d’un principe actif.

Pharmacokinetics and distribution of active ingredients. Understand the mechanisms of biotransformation and biodistribution of an organic compound in a living organism. Select and implement appropriate methods to evaluate the effects of the living system on the compound's structural integrity. Extrapolate in vitro and in vivo measurements to another species (including humans).

Case studies in pharmaceutical research and development. Search for information in "primary" scientific literature. Identify the key stages of a recent drug discovery program (from target validation to preclinical candidate) and present your research in a slide show.

Modeling and measuring molecular interactions in drug discovery.

Optional skills :

Skills based on factual knowledge :

Major advances in therapeutic chemistry as a prerequisite for drug design: Central Nervous System drugs.

Major advances in therapeutic chemistry as a prerequisite for drug design: Cardiovascular, cancer and other specialties.

Knowledge of structure, mechanism of action and Structure-Property Relationships of currently available drugs to situate a new project in the current therapeutic arsenal.

Optional procedural skills :

 Know the HTS screening tool independently of read-out: advantages, practical application, constraints and limitations. Knowledge and application of high-throughput confocal microscopy techniques. Use of a ChemBioFrance National Research Infrastructure platform.

Chemical strategies for target validation and drug candidate identification. Design and implement chemical and analytical methods to obtain labeled or unlabeled pharmacological probes. Design, prepare and assemble focused and unfocused chemical libraries.